Wash hands with soap and water.
Gently rub the tomato and lettuce under cold running water. Do not rinse raw meat.
Slice tomatoes and lettuce.
Add ground turkey to a medium mixing bowl. Sprinkle in breadcrumbs, salt, pepper, garlic powder, and onion powder. Add mayonnaise and drizzle in Worcestershire sauce.
Gently toss and break up meat mixture to evenly blend. Divide into 4 equal portions and shape into patties about 1/2-inch thick.
Wash hands with soap and water. Wash utensils after touching raw meat.
Preheat olive oil in a 12-inch non-stick skillet over medium-high heat for a few minutes.
Add turkey patties and sear until golden brown on bottom, about 4 – 5 minutes, flip and continue to cook until cooked through, about 4 – 5 minutes longer. Cook until internal temperature reaches 165 °F on a food thermometer.
Serve warm in hamburger buns with toppings of choice.